Cloning of human stem cells, we - RaiNews24

Salem, 05/16/2013

human skin cells transformed into human embryonic stem cells, capable of becoming
in another type of body cells: tissues, or organs. The discovery, reported by ‘Cell’ was made by a group of scientists from the Oregon Health and Science University.

The scientists used the same technique in research in 1996 had
product Dolly the sheep, the transplant of genetic material from an adult cell into an egg that had removed the DNA. The unfertilized egg cell was developed and produced stem.

“A significant step forward in the development of cells that can be used in regenerative medicine,” said the head of the medical Shoukhrat Mitalipov. To date, the majority of human embryonic stem cells were derived from embryos, a practice that has always ethical problems.

Into turned back on so ‘the dream of therapeutic cloning, which aims to produce reserves of cells of the same patients for therapies to combat diseases such as Parkins on’s, multiple sclerosis and spinal cord injury
.

The study published in ‘Cell’ is a collaborative effort between the Oregon Health and Science University (Ohsu) Primate Research Center and Oregon (ONPRC). The
research group, coordinated by Shoukhrat Mitalipov, has transferred the nucleus of a cell within an egg cell from which it was previously removed the core, which is enclosed in the Dna. Once transferred, the adult cell from the inside began to receive a series of signals to the oocyte which led it to turn back and return gradually in the development, up to
become an undifferentiated cell as an embryonic cell .

Cells obtained with this technique, Mitalipov said, “have demonstrated the ability to transform into different types of tissue, just like the normal embryonic cells, giving rise to cells of the brain, liver and heart “. And without problems of rejection because they are drawn from the patient’s own cells targeted by the treatment.

This new breakthrough comes after numerous attempts made in the years immediately following the birth of Dolly, but failed . So much so that as of 2006, the road to the reprogramming of cells was based on the technique introduced by
Japanese Shinya Yamanaka, which involves the stimulation of the cells with a cocktail of four genes. However, the Oregon researchers have never given up. The same Mitalipov in 2007 had obtained from monkey embryonic stem cells using nuclear transfer. Since September 2012, the goal of his group was to achieve the same goal with human cells